SchrodingerCrackDownloadMy 1. TED talks You may be thinking, What does this have to do with nutrition Or exercise Or ketosis Or the other things Peter obsesses over  Well, technically, nothing. But since this is a personal blog, I figure every once in a while I can write something for my friends or family members who have zero interest in nutrition or ketosis or VO2 maxes or FTP or RQ or LDL P this list of folks is actually quite long. I remember the first time I ever watched a TED talk in the summer of 2. My first thought was, Hey this is great. How have I never heard of these, especially since this conference has been going on since 1. Well, back in the 8. I dont think the talks were posted online, so perhaps I can be forgiven. If youre so inclined, Id invite you to watch these talks over the next few weeks. Guest essay by Dr. Pat Michaels Under the U. S. Global Change Research Act of 1990, the federal government has been charged with producing large National. Welcome This website has been created on behalf of Rob Burbea. There are so many of us around the world who care deeply for Rob and we offer this page as a way. Pg4N6z.jpg' alt='Schrodinger Crack Download' title='Schrodinger Crack Download' />Or, if youre OCD like me, you may just watch them all in one sitting. I hope they speak to you in the way they have spoken to me. And I hope youll share your favorites back with me. Im always up for a great TED talk. Ok, so on to my list. First of all, this was very difficult to narrow down. If there is a nine way tie for 2nd place, below, there is a 2. Also, picking a favorite talk is like picking a favorite food or drink. It sort of depends on what youre craving. Each of these talks means something different to me. Depending on my need at the moment, I guess my appetite for each one varies over time. My favorite TED talk. If you read the post I wrote after the TEDMED conference this year, youll recall that I specifically called out my all time favorite TED talk, that of Ric Elias. Any time and every time I feel like Im losing sight of things, I fire up Rics talk or just call Ric for a pep talk hes that gracious with his time. Ric has become a friend and real mentor, especially as I navigate my way through fatherhood. Schrodinger Crack Download' title='Schrodinger Crack Download' />Ric Elias 3 things I learned while my plane crashed. Nine way tie for my second favorite TED talk in no particular orderIm not sure how I stumbled onto this talk. I actually saw it shortly after it was posted, and it has now been seen by millions. Like others, I became completely transfixed by Davids story. We share a few traits, such as self experimentation and extreme activity. But, I think it goes far beyond that. In fact, I know it does. What moves me when watching this talk is the passion and vulnerability he showed. Ive never met David, but hope to do so one day. David Blaine How I held my breath for 1. Imagine a world with 1,0. Dean Kamens in itWhen youre done watching this, youll get what I mean. As an engineer I can relate to the restless desire to fix things, but Deans humanity and compassion for the men and women he wants to heal is actually palpable in this talk. Dean is on the Board of the Salk Institute, located here in San Diego, so I secretly hope to run into him one day when hes here. It may never happen, but Ill keep dreaming. Dean Kamen The emotion behind invention. About a year ago someone sent me this talk and said, Peter, watch thisI bet it completely explains how you feel. I couldnt believe it. Susan Cain so eloquently explains what it feels like to be an introvert in a world that, at times, feels like its designed for extroverts. Susan does such a great job explaining the distinction between introversion and shyness anyone who knows me knows Im far from shy, but still very introvertedthis is a seemingly awkward combination for people to engage with. Watching this talk and reading the book she wrote on the same topic have validated many of the insecurities I have about my introversion. Susan Cain The power of introverts. Perhaps I would not find this talk so amazing if not for the fact that my job is running a non profit. I must admit, I had always held to the typical beliefs of overhead is bad in the non profit world. Dan makes a very compelling case for why this anachronistic view may be impeding progress in the non profit space. Dan is also on the list of folks I hope to meet one day. Dan Pallotta The way we think about charity is dead wrong. A couple of weeks before I was to give my talk at TEDMED this year, my sister emailed me this talk with the question, Hey Pete, have you ever heard of TED You should definitely check this out. Youll love this talk, to which I responded, Yea, I thinkIve heard of TEDoh, yea, I have. Thanks for sending. I didnt have the heart to be that much of a wise guy and say I was obsessed with TED and was giving a talk a few weeks later. But coming from my sister, I knew I would like it. I simply couldnt take my eyes off the screen as Shane mixed poetry and rage in emotional appeal. Id give anything to meet Shane one day, and I hope every kid in high school watches this. Shane Koyczan To This Day for the bullied and beautiful. I came across this talk pretty recently, shortly after it was posted in April of this year. Some have said that a truly great TED talk engages some part of your intellect and some part of your emotion, and ideally a bit of both. The talk definitely engages my intellect. The style and rhythm of Lawrences presentation is just amazing, and it really brings to light what I think most of us realize is a broken system in this country. He is simply a remarkable orator. Lawrence Lessig We the People, and the Republic we must reclaim. I saw this talk for the first time in mid 2. I think. I had certainly heard of Tony Robbins, even back in the late 1. I had never actually heard him speak. Im not sure why, because presentations by professionals dont typically appeal to me, but I find this talk really insightful. The story at the end is particularly moving. Tony Robbins Why we do what we do. I dont know how I came across Joshuas talk. I think I was just scrolling through recently released talks earlier this year. From the first moment, though, I was hooked. Can you imagine what he felt as he went along this journeyJoshua Prager In search of the man who broke my neck. Steve Levitt is a close friend, and so perhaps Im biased in my appreciation for his work, which goes well beyond this talk or his other equally provocative, but funnier talk on the economics of being a crack cocaine dealer. Perhaps because I find myself among a group of people challenging conventional wisdom, I find it so enjoyable to spend time and share ideas with a guy like Steve. He sure makes a lot of enemies daring to suggest the evidence supporting the use of car seats is not as cut and dry as the establishment would have us believe. Sound familiar Steven Levitt on child carseats. The night I gave my talk at TEDMED I remember getting back to my hotel after a reception. I wasnt very happy with how my talk went and was a bit disappointed in my inability to control my emotion, which I felt may have got in the way of the message I wanted to deliver. One of the folks on the editorial staff of TEDMED called me to say hi, and when I shared my disappointment with her, she suggested I watch this talk. I was amazed that I had missed it previously. Bren Brown The power of vulnerability. Bonus talkSince I saw this talk live, at 2. TEDMED, unlike the other 1. How Abilify Works, And Why It Matters. One lament of many in the mental health profession psychiatrists and pharmascolds alike is that we really dont know enough about how our drugs work. Sure, we have hypothetical mechanisms, like serotonin reuptake inhibition or NMDA receptor antagonism, which we can observe in a cell culture dish or sometimes in a PET study, but how these mechanisms translate into therapeutic effect remains essentially unknown. As a clinician, I have noticed certain medications being used more frequently over the past few years. One of these is Abilify aripiprazole. Ive used Abilify for its approved indicationspsychosis, acute mania, maintenance treatment of bipolar disorder, and adjunctive treatment of depression. It frequently but not always works. But Ive also seen Abilify prescribed for a panoply of off label indications anxiety, obsessive compulsive behavior, anger, irritability, and so forth. Can one medication really do so much  And if so, what does this say about psychiatryFrom a patients perspective, the Abilify phenomenon might best be explained by what it does not do. If you ask patients, theyll say thatin generalthey tolerate Abilify better than other atypical antipsychotics. Its not as sedating as Seroquel, it doesnt cause the same degree of weight gain as Zyprexa, and the risk of contracting uncomfortable movement disorders or elevated prolactin is lower than that of Risperdal. To be sure, many people do experience side effects of Abilify, but as far as I can tell, its an acceptable drug to most people who take it. Abilify is a unique pharmacological animal. Segoe Script Bold Font. Like other atypical antipsychotics, it binds to several different neurotransmitter receptors this signature theoretically accounts for its therapeutic efficacy and side effect profile. But unlike others in its class, it doesnt block dopamine specifically, dopamine D2 or serotonin specifically, 5 HT1. A receptors.   Rather, its a partial agonist at those receptors. It can activate those receptors, but not to the full biological effect. In lay terms, then, it can both enhance dopamine and serotonin signaling where those transmitters are deficient, and inhibit signaling where theyre in excess. Admittedly, thats a crude oversimplification of Abilifys effects, and an inadequate description of how a partial agonist works. Nevertheless, its the convenient shorthand that most psychiatrists carry around in their heads  with respect to dopamine and serotonin the two neurotransmitters which, at least in the current vernacular, are responsible for a significant proportion of pathological behavior and psychiatric symptomatology, Abilify is not an all or none drug. Its not an on off switch. Its more of a stabilizer, or, in the words of Stephen Stahl, a Goldilocks drug. Thus, Abilify can be seen, at the same time, as both an antipsychotic, and not an antipsychotic. Its both an antidepressant, and not an antidepressant. And when you have a drug that is a generally well tolerated, b seems to work by stabilizing two neurotransmitter systems, and c resists conventional classification in this way, it opens the floodgates for all sorts of potential uses in psychiatry. Consider the following conditions, all of which are subjects of Abilify clinical trials currently in progress thanks to clinicaltrials. Tourettes disorder postpartum depression methamphetamine dependence obsessive compulsive disorder OCD late life bipolar disorder post traumatic stress disorder PTSD cognitive deficits in schizophrenia alcohol dependence autism spectrum disorders fragile X syndrome tardive dyskinesia subsyndromal bipolar disorder whatever that is in children conduct disorder ADHD prodromal schizophrenia refractory anxiety psychosis in Parkinsons disease anorexia nervosa substance induced psychosis prodromal schizophrenia trichotillomania and Alzheimers related psychosis. Remember, these are the existing clinical trials of Abilify. Each one has earned IRB approval and funding support. In other words, theyre not simply the fantasies of a few rogue psychiatrists theyre supported by at least some preliminary evidence, or at least a very plausible hypothesis. The conclusion one might draw from this is that Abilify is truly a wonder drug, showing promise in nearly all of the conditions we treat as psychiatrists. Well have to wait for the clinical trial results, but what we can say at this point is that a drug which works as a stabilizer of two very important neurotransmitter systems can be postulated to work in virtually any way a psychopharmalogist might want. But even if these trials are negative, my prediction is that this wont stop doctors from prescribing Abilify for each of the above conditions. Why  Because the mechanism of Abilify allows for such elegant explanations of pathology we need to tune down the dopamine signal to get rid of those flashbacks or the serotonin 1. A effect might help with your anxiety yes, Ive heard both of these in the last week, that it would be anathema, at least to current psychiatric practice, not to use it in this regard. This fact alone should lead us to ask what this says about psychiatry as a whole. The fact that one drug is prescribed so widelyowing to its relatively nonspecific effects and a good deal of creative psychopharmacology on the part of doctors like meand is so broadly accepted by patients, should call into question our hypotheses about the pathophysiology of mental illness, and how psychiatric disorders are distinguished from one another. It should challenge our theories of neurotransmitters and receptors and how their interactions underlie specific symptoms. And it should give us reason to question whether the stories we tell ourselves and our patients carry more weight than the medications we prescribe. Related. This entry was posted on Tuesday, September 1. You can follow any responses to this entry through the RSS 2. You can leave a response, or trackback from your own site.